-5%
Micoderm Cream is prescribed for various fungal skin infections (dermatomycoses) including:
- Athlete’s foot (Tinea pedis)
- Ringworm of the body (Tinea corporis)
- Fungal infections of the hand (Tinea manuum)
- Jock itch (Tinea cruris) caused by Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum audouinii, Epidermophyton floccosum
- Candidiasis (yeast infections)
- Tinea versicolor
- Inflamed skin folds (intertrigo)
- Perianal fungal infections
- Angular stomatitis (cheilitis)
- Balanoposthitis
- Otitis externa (outer ear infections)
Micoderm Cream also provides rapid relief from itching (pruritus) often associated with fungal infections.
Pharmacodynamics:
Miconazole exhibits potent antifungal action against common dermatophytes and yeasts and also possesses antibacterial activity against some gram-positive organisms. It works by inhibiting an essential step in the production of ergosterol, a key component of the fungal cell membrane. The absence of ergosterol disrupts membrane integrity, leading to leakage of essential intracellular contents and cell death.
Pharmacokinetics:
Orally, miconazole has limited absorption (about 25–30%). When administered as an oral gel, it is partly absorbed and binds strongly to plasma proteins, mainly serum albumin and red blood cells. It undergoes hepatic metabolism, with less than 1% excreted unchanged in urine. The average elimination half-life ranges from 20 to 25 hours, with similar clearance in patients with kidney impairment.