Glucium D 750mg+50mg Tablet

Glucosamine:

• A natural amino sugar essential for the biosynthesis of glycosaminoglycans (GAGs) such as hyaluronic acid, keratan sulfate, and chondroitin sulfate.
• GAGs combine with proteins to form proteoglycans, the structural building blocks of cartilage.
• Supplementing with glucosamine sulfate increases glucosamine levels, promoting cartilage repair and supporting ligaments, tendons, nails, and connective tissues.
• Activates chondrocytes, enhancing GAG and proteoglycan production.
• Oral absorption: ~90%; metabolized in the liver and excreted via urine.

Diacerein:

• Used to treat osteoarthritis; has analgesic, anti-inflammatory, and antipyretic properties.
• Inhibits Interleukin-1 (IL-1), a key cytokine responsible for cartilage breakdown, showing disease-modifying effects in osteoarthritis.
• Oral bioavailability: 56%; best taken with food for increased absorption.
• Metabolized extensively in the liver; 35–60% excreted as metabolites in urine.