Stemetil 4mg 40pcs

Indications

Prochlorperazine Maleate is indicated-

To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions.

Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere’s disease and other inner ear disorders.

For the treatment of psychotic illness such as schizophrenia (hallucinations and hostility).

Acute mania.

For the short-term treatment of generalized non-psychotic anxiety.

Pharmacology

During the first and second trimesters of pregnancy: Because the safety of ketoprofen in pregnant women has not been established, it should be avoided during the first and second trimesters of pregnancy. During the third trimester of pregnancy: Prodenid is not recommended during the third trimester. Ketoprofen should not be used by nursing moms.

Dosage & Administration

Antiemetic-
Children (not recommended in children <10 kg or <2 years):

10-14 kg: 2.5 mg every 12-24 hours as needed;maximum: 7.5 mg/day

15-18 kg: 2.5 mg every 8-12 hours as needed;maximum:10 mg/day

19-39 kg: 2.5 mg every 8 hours or 5 mg every 12 hours as needed; maximum: 15 mg/day.

Adults: 5-10 mg 3-4 times/day;usual maximum:40 mg/day

Antipsychotic-
Children (not recommended in children <10 kg or <2 years):

2-12 years: 2.5 mg 2-3 times/day

Increase dosage as needed to a maximum daily dose of 20 mg for 2-5 years and 25 mg for 6-12 years

Adults: 5-10 mg 3-4 times/day; doses up to 150 mg/day may be required in some patients for treatment of severe disturbances

Nonpsychotic anxiety-

Adults: Usual dose: 15-20 mg/day in divided doses; do not give doses >20 mg/day or for longer than 12 weeks

Elderly: Initial: 2.5-5 mg 1-2 times/day; increase dose at 4 to 7 day intervals by 2.5-5 mg/day; increase dosing intervals (twice daily, thrice daily, etc) as necessary to control response or side effects; maximum daily dose should probably not exceed 75 mg in elderly; gradual increases (titration) may prevent some side effects or decrease their severity.

Prochlorperazine may be administered without regard to the meal.

Interaction

Alcohol, barbiturates, and other sedatives may have a more depressing effect on the CNS. Antacids, antiparkinson’s medications, and lithium may interfere with Prochlorperazine absorption. Propanolol and phenobarbital plasma concentrations may be affected by this medication.

Contraindications

 Hypersensitivity to prochlorperazine or any component of the formulation, severe CNS depression; coma; should not be used in children <2 years of age or <10 kg.

Side Effects

Drowsiness; jaw, neck, and back muscle spasms; fine worm-like tongue movements; rhythmic face, mouth, or jaw movements; slow or difficult speech; difficulty swallowing; restlessness and pacing; tremors; shuffling walk; skin rash; yellowing of the skin or eyes.

Pregnancy & Lactation

There has been no proof of this drug’s side effects during pregnancy or lactation.

Precautions & Warnings

Oral dosage form: Patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn’s disease) should use NSAIDs with caution because their condition may worsen. At the beginning of treatment, the renal function of patients with heart failure, cirrhosis and kidney disease, patients receiving diuretic therapy and patients with chronic renal failure, especially in elderly patients, should be carefully monitored. In these patients, the administration of ketoprofen can cause a decrease in renal blood flow caused by the inhibition of prostaglandins and cause renal degradation.

Patients with a history of mild to moderate hypertension and / or congestive heart failure should be cautious due to reports of fluid retention and edema associated with NSAID treatment.

It has been reported that there is an increased risk of atrial fibrillation associated with the use of NSAIDs. Hyperkalemia may occur, especially in patients with underlying diabetes, renal failure, and / or concurrent treatment with promoters of hyperkalemia. In these cases, the potassium content must be controlled.

Like other non-steroidal anti-inflammatory drugs, in the presence of infectious diseases, it should be noted that the anti-inflammatory, analgesic and antipyretic properties of ketoprofen can mask common signs of infection progression, such as fever.

For patients with abnormal liver function tests or a history of liver disease, transaminase levels should be assessed regularly, especially during long-term treatment. Rare cases of jaundice and hepatitis have been described as the use of ketoprofen.

If vision disorders such as blurred vision occur, treatment should be stopped. The use of non-steroidal anti-inflammatory drugs can affect female fertility and is not recommended for women who are trying to become pregnant. For women who have difficulty conceiving or are undergoing infertility testing, NSAID should be considered to be discontinued. 

Storage Conditions

Store below 30°C.Protect from light and moisture. Keep out of the reach of children.