Sindola 5mg Tablet 10pcs

Mirogabalin, the active ingredient in Sindola, belongs to the class of gamma amino acids and their derivatives. It works by selectively binding to the α2δ subunits of voltage-gated calcium channels (VGCCs), reducing calcium influx and neurotransmitter release in presynaptic neurons. This results in decreased hyper-excitability of neurons in the central nervous system (CNS).

Absorption and Distribution:

• Mirogabalin is rapidly absorbed, with a median time to peak plasma concentration of 0.5 to 1.5 hours.
• It has low plasma protein binding (~25%) and a volume of distribution ranging from 64-88L after single or repeated doses.

Metabolism and Excretion:

• Most of the drug (61-72%) is excreted unchanged through the kidneys, with a smaller portion (13-20%) metabolized by liver enzymes (specifically uridine 5′-diphosphate-glucuronosyltransferase isoforms).
• The elimination half-life is approximately 2-4.9 hours, with 99% excretion via the kidneys and only 1% through feces.