Gaba-P 50mg 10pcs

Indications

A drug called GABA-P 50 is used to treat pain that results from nerve damage (neuropathic pain) brought on by illnesses including diabetes, shingles (herpes zoster infection), spinal cord injury, and other issues. Additionally, it is utilized to alleviate broad muscle pain and stiffness in fibromyalgia patients. When combined with other medications, GABA-P 50, a member of the anti-epileptic drug class, can be used to treat some forms of seizures (fits). If other medications are ineffective, they may also be administered to treat the symptoms of excessive anxiety in generalized anxiety disorder.

Pharmacology

Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It doesn’t directly bind to the benzodiazepine, GABAA, or GABAB receptors. Pregabalin has a strong affinity for the alpha-2-delta site, which is an auxiliary subunit of voltage-gated calcium channels, in the tissues of the central nervous system. Pregabalin has a dose-independent oral bioavailability of 90%. With a half-life of 6.3 hours in individuals with typical renal function, it is primarily eliminated by the kidneys from the systemic circulation as an unmodified drug.

Dosage & Administration

• Pregabalin has a maximum suggested dose of 100 mg three times a day (300 mg/day) for neuropathic pain related to diabetic peripheral neuropathy in patients with creatinine clearance of at least 60 mL/min. The dosage should start at 50 mg three times a day (150 mg/day), and depending on effectiveness and tolerability, it may be increased to 300 mg/day within a week.
• Pregabalin is suggested for use in individuals with post-herpetic neuralgia at a dose of 75 to 150 mg twice daily, or 50 to 100 mg three times daily (150 to 300 mg/day). The dosage should start at 75 mg twice daily or 50 mg three times daily (150 mg/day), and depending on effectiveness and tolerance, it may be increased to 300 mg/day within a week.
• Adult patients with partial onset seizures may benefit from adjunctive medication, which is typically started at a total daily dose of no more than 150 mg (75 mg two times a day, or 50 mg three times a day). The dose may be increased to a maximum of 600 mg/day depending on how each patient responds and tolerates it.
• Treatment of Fibromyalgia: A daily dose of 300–450 mg of Pregabalin is advised for the treatment of this condition. The dosage should start at 75 mg twice a day (150 mg/day), and depending on effectiveness and tolerance, it may be increased to 150 mg twice daily (300 mg/day) after a week.
  The dosage range for neuropathic pain brought on by spinal cord damage is 150 to 600 mg per day. The beginning dosage is 75 mg twice daily, or 150 mg per day. Depending on effectiveness and acceptability, the dose may be increased within a week to 150 mg twice daily (300 mg/day).
• You can take pregabalin capsules regardless of mealtime.

Interaction

Pregabalin has no notable interactions with other antiepileptic medicines or oral contraceptives. The effects of ethanol and lorazepam may be amplified by pregabalin.

Contraindications

Patients who have a known hypersensitivity to Pregabalin or any of its components should avoid using it.

Side Effect

Dizziness, somnolence, dry mouth, edema, impaired vision, weight gain, and aberrant thinking are the most prevalent adverse effects.

Pregnancy & Lactation

Pregabalin has a pregnancy category of C. As a result, it should only be taken if the potential benefit outweighs the dangers to the fetus.

Pregabalin, like other medications, can pass into the breast milk, therefore it should only be used in nursing mothers if the benefits clearly outweigh the risks.

Precautions & Warnings

Without tapering, pregabalin withdrawal may result in insomnia, nausea, headaches, and diarrhea. As a result, it should be discontinued gradually over a minimum of one week rather than stopped immediately. Your creatinine kinase level could increase if you use Pregabalin. It should be stopped right away if myopathy is seen or suspected, or if creatinine kinase levels are unusually high.

Storage Conditions

Keep away from light and moisture in a cool, dry area (below 30° C). Keep out of children’s reach.