Taglimet 50/500mg Tablet
Taglimet 50/500mg Tablet Original price was: 90.00৳ .Current price is: 85.50৳ .
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Targaba 15 Tablet 1 Strip
Targaba 15 Tablet 1 Strip Original price was: 630.00৳ .Current price is: 598.50৳ .
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Targaba 10 Tablet 1 Strip

SKU: 7159

Manufacturer: Opsonin Pharma Limited

Generic: Mirogabalin Besylate

Type: Tablet

Pack Size: 14 pcs

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Description

Targaba tablets are prescribed for the treatment of various types of neuropathic pain, including:

  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Postherpetic Neuralgia (PHN)
  • Peripheral Neuropathic Pain (PNP)

Mirogabalin is a derivative of gamma-aminobutyric acid (GABA) that targets the α2δ subunits of voltage-gated calcium channels (VGCCs). By inhibiting calcium ion influx and neurotransmitter release at presynaptic neurons, it helps reduce the hyperexcitability of neurons in the central nervous system (CNS), thereby relieving neuropathic pain.

After oral administration, Mirogabalin is quickly absorbed, with peak plasma concentrations occurring within 0.5 to 1.5 hours. It has low protein binding (about 25%) and a volume of distribution ranging from 64 to 88 liters. The drug is primarily excreted unchanged by the kidneys (61–72%), with minor hepatic metabolism mediated by UGT enzymes. Its elimination half-life ranges from 2 to 4.9 hours. Nearly all the drug is expelled through urine, with only 1% excreted in feces.