-5%
Largix is used for the relief of symptoms associated with Seasonal & Perennial Allergic Rhinitis and Urticaria.
- Elderly: Use with caution; no dose adjustment data.
- Children <12 years: Safety/efficacy not established.
- Renal/hepatic impairment: Not recommended.
Rupatadine is a long-acting, non-sedating H1 receptor antagonist with an additional ability to block platelet activating factor (PAF). Since both histamine and PAF contribute to bronchoconstriction, vascular permeability, and inflammation, this dual mechanism provides enhanced therapeutic benefit compared to antihistamines alone. Rupatadine also prevents mast cell degranulation and reduces the release of inflammatory cytokines such as TNF-α, contributing to its strong anti-allergic action.