-5%
Darbepoetin alfa is an erythropoiesis-stimulating agent (ESA) produced using recombinant DNA technology in Chinese Hamster Ovary (CHO) cells. It is a 165-amino-acid glycoprotein that differs from recombinant human erythropoietin by the presence of five N-linked oligosaccharide chains instead of three.
The additional glycosylation sites result from specific amino acid substitutions, leading to a prolonged serum half-life and sustained stimulation of red blood cell production.
Darbetin is indicated for the treatment of anemia associated with:
Chronic Kidney Disease (CKD) in adult and pediatric patients, including those receiving dialysis and those not on dialysis
Myelosuppressive chemotherapy–induced anemia in patients with non-myeloid malignancies, where at least two additional months of planned chemotherapy remain at the time of treatment initiation
Do not shake or freeze
Protect pre-filled syringes from light
Inspect visually for particulate matter or discoloration prior to use
Do not dilute or mix with other injectable solutions
Discard any unused portion of the pre-filled syringe