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Ninacent 150 | 10 Capsules

SKU: 11479

Manufacturer: Incepta Pharmaceuticals Ltd.

Generic: Nintedanib

Type: Capsule

Pack Size: 10 Pcs

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Description

Ninacent is prescribed for adults in the treatment of:

  • Idiopathic Pulmonary Fibrosis (IPF)
  • Chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype
  • Systemic sclerosis-associated interstitial lung disease (SSc-ILD)

Locally advanced, metastatic, or recurrent non-small cell lung cancer (NSCLC) of adenocarcinoma histology, in combination with docetaxel, following first-line chemotherapy

Nintedanib is a multi-targeted tyrosine kinase inhibitor that blocks the activity of several receptor and non-receptor tyrosine kinases implicated in fibrosis and tumor progression.
It competitively inhibits receptors such as:

PDGFR-α/β (platelet-derived growth factor receptors)

FGFR 1–3 (fibroblast growth factor receptors)

VEGFR (vascular endothelial growth factor receptors)

FLT3, Lck, Lyn, and Src

By binding to the ATP-binding sites of these receptors, Nintedanib disrupts downstream pathways responsible for:

Fibroblast proliferation and migration

Angiogenesis in tumors

Progression of pulmonary fibrosis