Bukof 50 Tablet 1 Strip

Bukof contains Butamirate Citrate, which acts directly on the brain’s cough center to suppress coughing.
It is a non-opioid, non-sedating antitussive, unrelated to opium derivatives.

After oral administration, it is rapidly absorbed, reaching peak levels (for sustained-release form) within about 9 hours. It is highly protein-bound, with an elimination half-life of approximately 13 hours. Its active metabolites also contribute to cough suppression.

Dosage & Administration

Adults

• Tablet (50 mg): 2–3 tablets daily
• Syrup: 15 ml, 4 times daily

Children & Adolescents

• Tablet (≥12 years): 1–2 tablets daily
• Syrup:
  • 3–6 years: 5 ml, 3 times daily
  • 6–12 years: 10 ml, 3 times daily
  • Adolescents: 15 ml, 3 times daily
• Pediatric Drops:
  • 2 months–1 year: 0.5 ml, 4 times daily
  • 1–3 years: 0.75 ml, 4 times daily

Drug Interactions

• Avoid using with expectorants, as it may lead to mucus accumulation in the airways

Contraindications

• Known hypersensitivity to Butamirate Citrate or any component

Adverse Effects

Bukof is generally well tolerated. Rare side effects may include:

• Rash
• Nausea
• Diarrhea
• Dizziness

These usually resolve after dose adjustment or discontinuation.

Pregnancy & Lactation

• First trimester: Not recommended
• Later pregnancy: Use only if prescribed, with caution
• Breastfeeding: Use only if benefits outweigh potential risks, as data are limited

Precautions & Warnings

• Do not combine with expectorants (risk of mucus retention and bronchospasm)
• Consult a doctor if:
  • Cough persists >7 days in adults
  • Cough persists >3 days in children under 12

Overdose Effects

Symptoms may include:

• Drowsiness
• Nausea, vomiting, diarrhea
• Loss of balance
• Low blood pressure

Management includes supportive care such as activated charcoal and standard emergency treatment.

Therapeutic Class

• Cough suppressant (antitussive)

Storage Conditions

• Store below 30°C
• Protect from light and moisture
• Keep out of reach of children