-2%
Coughex is used for the treatment of:
- Refractory chronic cough (persistent cough unresponsive to treatment).
- Unexplained chronic cough in adults.
- Gefapixant is a P2X3 receptor antagonist.
- Mechanism of action:
- P2X3 receptors are found in sensory C-fibers of the vagus nerve.
- Inflammation releases ATP, which binds to P2X3 receptors, triggering a cough reflex.
- Gefapixant blocks ATP-mediated activation, reducing chronic cough.
