Mirez 7.5mg Tablet 1 Strip

Pharmacodynamics:

• The exact mechanism is unknown, but Mirtazapine enhances noradrenergic and serotonergic activity.
• It acts as an α2-adrenergic receptor antagonist, leading to increased neurotransmitter release.
• It blocks 5-HT2 and 5-HT3 receptors, contributing to its antidepressant effects.
• Its H1 receptor antagonism explains its sedative properties.
• Moderate α1-adrenergic and muscarinic antagonism may cause orthostatic hypotension but results in fewer anticholinergic side effects.

Pharmacokinetics:

• Rapidly absorbed after oral administration, reaching peak levels in ~2 hours.
• 85% plasma protein binding.
• Elimination half-life: 20-40 hours (26 hours in males, 37 hours in females).
• Metabolized via demethylation, oxidation, and conjugation, excreted through urine and feces.