-5%
Nikethamide 250 mg/ml Injection is used for the treatment, control, prevention, and improvement of the following diseases, conditions, and symptoms: Central nervous system stimulant, Barbiturate overdose.
Nikethamide Injection is a respiratory stimulant primarily used to address respiratory depression caused by conditions like chronic bronchitis. It can also be employed to counteract overdoses of tranquilizers, sedatives, and barbiturates before procedures like endotracheal intubation and lung expansion. Additionally, it serves as a central stimulant and aids in managing hypotensive disorders.
Commonly known as nicotinic acid diethylamide, Nikethamide functions similarly to doxapram. However, the dosage required for respiratory stimulation is lower than that which induces convulsions in conscious individuals. In regions like South America and Europe, Nikethamide is available in lozenge form as an over-the-counter drug for short-term use to enhance endurance in high-altitude environments. Moreover, it exerts a direct influence on the heart by promoting coronary flow in cases of myocardial infarction.
The mechanism of action of Nikethamide involves direct interaction with the respiratory centers in the brain. It is typically administered intravenously by healthcare professionals in hospital or clinic settings. Each milliliter of solution contains 250 mg of nikethamide.