-2%
Frusemide (a loop diuretic) and Spironolactone (a potassium-sparing diuretic) act on different parts of the renal tubules and offer complementary diuretic effects.
Frusemide inhibits the Na⁺/K⁺/2Cl⁻ cotransporter in the loop of Henle, enhancing excretion of sodium, potassium, and chloride, resulting in significant fluid loss.
Spironolactone counters potassium loss by blocking aldosterone at the distal tubule, promoting sodium excretion while conserving potassium.
This combination is used to manage:
- Essential hypertension
- Chronic congestive heart failure
- Cirrhosis of the liver with ascites
- Edema from fluid retention
- Primary and secondary hyperaldosteronism
- Edema resistant to standard treatment, linked to aldosterone excess