-2%
Hormone replacement therapy (HRT) for the treatment of:Â
- Climacteric syndrome in postmenopausal women, including vasomotor symptoms (such as hot flushes and sweating attacks), sleep disorders, depressed moods, nervousness, and atrophic urogenital conditions caused by deficient endogenous estrogen production due to natural menopause, hypogonadism, castration, or primary ovarian failure in women with an intact uterus.
- Prevention of postmenopausal osteoporosis.
Angela Tablet contains 17β-estradiol, which is chemically and biologically identical to the natural human estrogen (E2), and drospirenone (DRSP), a synthetic progestogen. Estradiol serves as a hormone replacement both during and after menopause, while drospirenone helps regulate bleeding and prevents endometrial hyperplasia that may result from estrogen therapy.
Effects of Estradiol:
The decline in ovarian function during menopause causes a significant reduction in estrogen and progesterone levels, leading to menopausal symptoms such as vasomotor instability and organic changes. Hormone replacement therapy (HRT) helps relieve these symptoms. Among all physiological estrogens, estradiol (E2) has the strongest estrogenic activity, showing the highest affinity for estrogen receptors.
Primary target organs of estrogen include the uterus, hypothalamus, pituitary gland, vagina, breasts, and bones (osteoclasts).
Other notable effects of estrogens include reducing insulin and blood glucose levels, producing local vasoactive responses through receptor-mediated actions, and receptor-independent effects on vascular smooth muscle. Estrogen receptors are also present in the heart and coronary arteries. Oral administration of natural estrogens can be beneficial in some hypercholesterolemia cases, enhancing liver metabolism and promoting favorable lipid profile changes.