-5%
- Novaclav 1.2 IV Injection is used for the management of various bacterial infections
1.2 gm vial: Reconstitute with 20 ml Water for Injection
- Do not mix with dextrose, sodium bicarbonate, protein hydrolysates, blood, plasma, or IV lipids
- May be administered through drip tubing containing glucose, dextran, or bicarbonate solutions over 3–4 minutes
Novaclav is recommended for short-term management of various bacterial infections, including:
- Upper respiratory tract infections such as tonsillitis, sinusitis, and otitis media
- Lower respiratory tract infections including acute or chronic bronchitis, lobar pneumonia, and bronchopneumonia
- Genitourinary infections such as urethritis, cystitis, and pyelonephritis
- Skin and soft tissue infections
- Bone and joint infections, including osteomyelitis
- Other infections, for example, intra-abdominal sepsis, puerperal sepsis, and septic abortion
Pharmacodynamics
- Novaclav combines Amoxicillin, a broad-spectrum bactericidal penicillin antibiotic, with Clavulanic Acid, a β-lactamase inhibitor.
- Amoxicillin is effective against many Gram-positive and Gram-negative bacteria but can be destroyed by β-lactamase–producing organisms.
- Clavulanic Acid blocks these enzymes, protecting Amoxicillin from degradation.
This extends the overall antimicrobial spectrum to include resistant strains.
Pharmacokinetics
- Both components are absorbed quickly, with peak blood levels reached approximately 1 hour after oral intake.
- Maximum absorption occurs when taken at the start of a meal.
- About 70% of each component remains unbound in serum.
- Doubling the dose results in proportional increases in blood concentrations.