-5%
Targaba is recommended for the treatment of various types of neuropathic pain, including:
- Neuropathic pain in general
- Diabetic peripheral neuropathy (DPNP)
- Postherpetic neuralgia (PHN)
- Peripheral neuropathic pain (PNP)
Mirogabalin, a derivative of gamma-aminobutyric acid (GABA), works by selectively binding to the α2δ subunits of voltage-gated calcium channels. This action reduces calcium influx in neurons, limiting the release of excitatory neurotransmitters. By suppressing neurotransmission, it helps diminish the hyperactivity of central nervous system (CNS) neurons associated with neuropathic pain.
Absorption: Rapid after oral intake; peak plasma levels reached within 0.5 to 1.5 hours.
Distribution: Low protein binding (~25%); volume of distribution: 64–88 L.
Metabolism & Excretion: Eliminated mainly unchanged via renal excretion (61–72%). Minor hepatic metabolism via UGT enzymes. Mean half-life: 2–4.9 hours. About 99% is excreted in urine, and 1% via feces.