-5%
Tolfenamic Acid | Namitol is used for:
- Relief of migraine headache pain
- Management of post-operative pain
- Reduction of fever
Tolfenamic acid is a fenamate NSAID that inhibits cyclooxygenase (COX) enzymes, thereby reducing the synthesis of inflammatory mediators such as prostaglandin E2 (PGE2) and thromboxane B2 (TXB2). This action decreases pain, swelling, and inflammation. Additionally, it has a direct antagonistic effect on prostaglandin receptors.
Pharmacokinetics:
Absorption: Rapid from the gastrointestinal tract; peak plasma concentration in 60–90 minutes
Bioavailability: ~85%
Distribution: 99% protein-bound
Half-life: 2 hours
Metabolism: Liver; undergoes enterohepatic circulation
Excretion: Mainly via urine (~90%) and feces
