-2%
Flunarizine is a difluorinated derivative of cinnarizine and acts as a selective calcium channel blocker. It reduces excessive calcium entry into cells, thereby preventing cellular calcium overload while preserving normal calcium balance. In addition, it possesses mild antihistaminic and sedative properties. Approximately 99% of the drug binds to plasma proteins.
Tigover is used for the prevention of migraine attacks, including both classic migraine (with aura) and common migraine (without aura). It is also indicated for the symptomatic treatment of vestibular vertigo resulting from functional vestibular disorders, peripheral vascular disease (PVD), motion sickness, and as an adjunctive therapy in refractory epilepsy that does not respond adequately to conventional antiepileptic medications.
Pharmacology
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Dosage and Administration
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Drug Interactions
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Precautions and Warnings
Tigover may cause drowsiness, which can be worsened by alcohol or other central nervous system depressants. Patients should avoid driving or operating machinery until they know how the medication affects them.
This medication is intended for migraine prevention and should not be used to stop an acute migraine attack. Increasing the dose during a migraine episode is not recommended.
Flunarizine may induce depressive symptoms, extrapyramidal reactions, or unmask Parkinsonism, particularly in elderly individuals and those predisposed to these conditions. Regular monitoring is advisable during long-term therapy.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Therapeutic Class
Other drugs used for migraine prevention.