-2%
Baclofen, the active component of Bacifen, is a GABA-B receptor agonist that acts within the spinal cord to suppress both monosynaptic and polysynaptic reflexes. This inhibition reduces the release of excitatory neurotransmitters like glutamate and aspartate, effectively diminishing muscle tone and spasticity.
Additionally, Baclofen exhibits CNS depressant and antinociceptive (pain-reducing) effects, contributing to overall muscle relaxation and relief from discomfort.
Bacifen is prescribed to alleviate spasticity resulting from various neurological and musculoskeletal conditions. It is particularly effective in:
- Muscle stiffness, spasms, and rigidity associated with multiple sclerosis
- Flexor spasms, clonus, and muscle tightness, causing pain or movement difficulty
- Spinal cord injuries and other spinal diseases leading to muscle spasm
- Spasticity following cerebrovascular accidents (strokes)
- Muscle hypertonia due to neoplastic or degenerative brain disorders
- Skeletal muscle spasms caused by rheumatic conditions