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Collagen type II (native) is a protein that is part of cartilage, bone, and other types of connective tissues in animals and humans.
Collagen type II might work by causing the body to produce chemicals that fight pain and swelling. But this is unproven. Most collagen type II found in supplements comes from chicken. Some collagen type II in supplements comes from cows.
Collagen type II is used for osteoarthritis. It is also used for other types of joint and muscle pain, but there is no good scientific evidence to support these other uses.
Don’t confuse collagen type II (native) with collagen peptides, collagen type I (native), or gelatin.
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Possibly Effective for
- Osteoarthritis. Taking collagen type II by mouth for up to 6 months seems to improve self-reported symptoms of osteoarthritis, such as stiffness and pain. But it’s not clear if it can prevent the narrowing of the joint in people with osteoarthritis.
Possibly Ineffective for
- Rheumatoid arthritis (RA). Taking collagen type II by mouth doesn’t improve symptoms of RA. In fact, using it in place of drugs for RA, such as methotrexate, might make symptoms worse.
There is interest in using collagen type II for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.