-5%
Indications:
- As a medical alternative to surgical termination of intra-uterine pregnancy
- Softening and dilatation of the cervix uteri prior to surgical pregnancy termination
- Preparation for the action of prostaglandin analogues in the termination of pregnancy for medical reasons
- Labour induction for the expulsion of a dead fetus (fetal death in utero).
Side Effects:It is very common for women to experience uterine contractions or cramping (10-45%) in the hours following prostaglandin intake. Bleeding increases with gestational age. Heavy bleeding occurs in about 5% of cases and from 0-1.4% may require haemostatic curettage. Uterine rupture, hypotension, skin rashes, urticaria, hot flashes and dizziness have been uncommonly reported.Single doses of Mifepristone up to 2 gm caused no unwanted reaction. In the event of massive ingestion, signs of adrenal failure might occur. Acute intoxication may require admission to hospital and if relevant treatment with dexamethasone.Store at 25° C.