-5%
Ketoprofen, the active ingredient in Profenid-E, is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, pain-relieving, and fever-reducing effects. It works by:
- Inhibiting prostaglandin synthesis.
- Stabilizing lysosomal membranes (both in vitro and in vivo).
- Reducing leukotriene synthesis at high concentrations.
- Demonstrating anti-bradykinin activity (in vivo).
Ketoprofen’s analgesic properties arise from its ability to inhibit prostaglandin production both centrally and peripherally. Its antipyretic effect may be due to suppressing prostaglandin synthesis in the CNS, particularly in the hypothalamus.
Profenid-E is recommended for managing conditions due to its anti-inflammatory, analgesic, and antipyretic properties. It is used for:
- Treating rheumatoid arthritis.
- Managing degenerative joint diseases.
- Addressing musculoskeletal and joint issues like tendinitis and sprains.
- Alleviating pain, such as dental pain, headaches, or primary dysmenorrhea.
Use medications as advised by a registered physician. - Ketoprofen is quickly and completely absorbed via the gastrointestinal tract.
- Approximately 99% of it binds to plasma proteins, primarily albumin.
- The elimination half-life ranges from 1.1 to 4 hours.
- The drug is primarily metabolized in the liver through glucuronidation and excreted via urine (50-90%) and feces (1-8%) within 1-5 days.
- Intramuscular administration results in peak levels of ~10 mg/L within 0.5 to 0.75 hours for a 100 mg dose, with a half-life of approximately 1.88 hours.