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Tablet, Generic Name: Naproxen 500 mg
Naproxen is indicated for the relief of symptoms of rheumatoid arthritis, both of acute flares and long term management of the disease. It is also used in the diseases of rheumatoid osteoarthritis (degenerative arthritis), ankylosing spondylitis, juvenile rheumatoid arthritis, tendinitis, brusitis, acute gout, acute musculoskeletal disorders (such as sprains, direct trauma and fibrositis), migraine and dysmenorrhoea.
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Dosage:Â Tablet & Suppository (Adult)-
- Rheumatic disorders:Â The usual initial dose of naproxen is 250 mg twice daily adjusted to 500 mg to 1000 mg daily in 2 divided doses.
- Juvenile arthritis:Â A dose of 10 mg/kg body weight daily in 2 divided doses is used for children over 5 years of age.
- Acute gout:Â An initial dose of 750 mg followed by 250 mg every 8 hours.
- Dysmenorrhoea:Â 500 mg may be given initially followed by 250 mg in every 6-8 hours.
Syrup (Children over 5 years)-
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- In juvenile arthritis: The usual dosage of Naproxen is 10 mg/kg/day taken in two doses at 12-hour intervals is recommended.
Gel:Â Naproxen gel is to be applied 2-6 times a day as required and is not recommended for use in children.
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Side effects:Â Gastro-intestinal discomfort: nausea, diarrhoea and occasionally bleeding and ulceration.
Hypersensitivity reactions: notably with bronchospasm, rashes and angioedema.
CNS side effect: drowsiness, headache, fluid retention, vertigo, hearing disturbances such as tinnitus, photosensitivity.
A few instances of jaundice, impairment of renal function, thrombocytopenia, and agranulocytosis have been reported.