-5%
Indication
Treatment or prevention of, Vitamin C Deficiency, Scurvy, Infection, Trauma, Burns, Cold exposure, Following Surgery, common cold, Fever, scurvy, Stress, Cancer, Methemoglobinemia and Children receiving unfortified formulas. Also indicated in, Hematuria, Dental Caries, Gum Diseases, Pyorrhea, Acne, Infertility, Atherosclerosis, Fractures, Leg ulcers, Hay fever, Vascular thrombosis prevention, Levodopa toxicity, Arsenic toxicity.
Administration
May be taken with or without food. IV Preparation Dilute with large volume of compatible fluid to minimize adverse reactions Compatible w/ most common diluents (dextrose solons, NS, LR, Ringer’s, ½NS, dextrose-saline, dextrose-LR etc) IV Administration Avoid rapid infusion
Adult Dose
Oral Scurvy Adult: Prevention: 25-75 mg daily. 4 tablets 2 to 3 times daily. Treatment: >250 mg daily, given in divided doses. May also be given via IM/IV/SC admin. 250-500mg IV qDay/BID for at least 2 weeks. Thalassemia Adult: 100-200 mg daily, to be given with deferoxamine. Common cold: 1 gm or more daily in divided doses, i.e. 4 tablets daily. In wound healing: 2-4 tablets 2 to 3 times daily In other conditions: 1-2 tablets daily For the reduction of risk of stroke in the elderly: 1-2 tablets daily. 1 effervescent tablet daily with a meal or as directed by physician. Dissolve one tablet in half glass (100 ml) of water and drink instantly.
Child Dose
Children: Child: 1 mth-4 yr: 125-250 mg daily; 4-12 yr: 250-500 mg daily; 12-18 yr: 500 mg-1 g daily. Doses to be given in 1-2 divided doses. Thalassemia Child: 100-200 mg daily, to be given with deferoxamine. Metabolic disorders Child: Neonate: 50-200 mg daily, adjust if needed; 1 mth-18 yr: 200-400 mg daily in 1-2 divided doses, up to 1 g daily may be needed.
Mode of Action
Vitamin C: Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to fulminic acid.
Precaution
Should be given with caution to patient with hyperoxaluria.
Side Effect
Flushing, Flank pain, Faintness, headache, Diarrhea, dyspepsia, nausea, vomiting, Hyperoxaluria (large doses)
Interaction
Vit C: Deferoxamine, hormonal contraceptives, fluphenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.