-2%
Folate is recommended in a variety of conditions, including:
- During pregnancy and lactation, to prevent neural tube defects in developing fetuses.
- As a nutritional supplement for adults and the elderly.
- To reduce the risk of spontaneous miscarriage.
- For postmenopausal women, it helps to regulate homocysteine levels and support cardiovascular, bone, and menopausal health.
- In cases of folate deficiency due to medications such as anticonvulsants (e.g., phenytoin, phenobarbital, primidone).
- In patients undergoing long-term red blood cell damage or renal dialysis.
- As supportive therapy in depression, cognitive decline, dementia, and Alzheimer’s disease.
Folate is a water-soluble B vitamin that serves as a coenzyme in DNA and RNA synthesis and amino acid metabolism. During pregnancy, a deficiency can result in serious fetal abnormalities like neural tube defects (NTDs), including spina bifida and anencephaly. Adequate folate levels are essential to reduce risks of preterm birth, low birth weight, and intrauterine growth restriction. Supplementation, especially prior to conception and in early pregnancy, effectively reduces NTD recurrence.
- Not recommended for individuals with known hypersensitivity to any component of the formulation.
- Generally well tolerated, but it’s advisable to consult a physician before initiating therapy.
- Folate is safe during pregnancy and compatible with breastfeeding. Supplementation may be necessary in lactating mothers with inadequate dietary intake to prevent megaloblastic anemia.