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Dehydroepiandrosterone (DHEA) is the body’s most abundant adrenal steroid hormone. It is naturally produced by the adrenal glands, liver, brain, and, in men, the testes. After production, DHEA is converted into male and female sex hormones, including androgens and estrogens, which regulate metabolism, reproductive health, hormone balance, energy production, and bone maintenance.
DHEA levels reach their highest point in early adulthood and gradually decline with age. It also acts within the brain as a neurosteroid, influencing nerve signaling and mood. Additionally, DHEA may support cardiovascular function by promoting nitric oxide production, improving blood vessel function, and reducing platelet aggregation.
DHEA is a hormone supplement commonly used to support reproductive and hormonal health. It may help improve fertility in women with reduced ovarian reserve by increasing the number of eggs and embryos during assisted reproduction. It is also used as a nutritional supplement to support the body’s natural DHEA levels.
DHEA may also be considered for supporting overall health in conditions such as:
- Adrenal insufficiency
- Hormonal imbalance
- Age-related decline in DHEA levels
- Bone health (including osteoporosis)
- Mood disorders and depression
- Memory and cognitive function
- Stress-related conditions
- Cardiovascular health
- Metabolic disorders, including diabetes and obesity
- Immune system support
- Erectile dysfunction
- Systemic Lupus Erythematosus (SLE)
- Certain allergic and inflammatory conditions
Use only under the guidance of a registered physician.
Dosage should be individualized according to the medical condition and physician’s recommendation.
Typical doses used in clinical studies include:
- Adrenal insufficiency: 50 mg once daily for 3 months; 200 mg daily has been used for pharmacological effects.
- Diminished ovarian reserve: 50–75 mg daily in divided doses.
- Anorexia nervosa: 100 mg daily for 6 months.
- Exercise-related muscle recovery: 100 mg daily for 5 days.
- Major depressive disorder: 30–450 mg daily for 6–8 weeks.
- Metabolic syndrome: 100 mg daily for 3 months.
- Postmenopausal women: 25–50 mg daily, depending on clinical need.
Children and adolescents: Not recommended for individuals under 18 years of age.
Take only as prescribed by a registered physician.
DHEA may interact with several medicines and medical conditions, including:
- Calcium channel blockers (may further increase DHEA levels)
- Glucocorticoids (may reduce natural DHEA production)
- Insulin (may alter DHEA-S levels)
- Triazolam (may increase its blood concentration)
- Medicines metabolized by the CYP3A enzyme system
It should also be used cautiously in individuals with:
- Diabetes
- Hormone-sensitive cancers
- Liver disease
DHEA should not be used in individuals with:
- Bipolar disorder or a history of mania
- Hormone-sensitive cancers such as breast, ovarian, or prostate cancer
- Known allergy to DHEA or any of its ingredients
Common side effects
- Acne
- Hair loss
- Increased facial hair growth in women
- Irritability
- Aggressive behavior
- Increased estrogen levels
Rare but serious side effects
- Rapid heartbeat
- Dizziness
- Blurred vision
Seek medical attention immediately if serious symptoms occur.
DHEA should not be used during pregnancy or while breastfeeding.
Consult your healthcare provider before using DHEA if you:
- Have a personal or family history of breast or prostate cancer
- Have heart disease
- Have enlarged prostate
- Have low HDL (“good”) cholesterol
- Have thyroid disorders or take thyroid medications
- Take prescription medicines or other dietary supplements
People with high blood pressure should avoid using DHEA unless advised by a healthcare professional.
Do not exceed the recommended dose, as excessive intake may increase the risk of adverse effects.
Store below 30°C, protected from light and moisture. Keep out of the reach of children.