-2%
Immense contains Sildenafil, a selective and reversible phosphodiesterase type 5 (PDE5) inhibitor. During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum, which increases cyclic guanosine monophosphate (cGMP) levels. Immense inhibits PDE5, preventing cGMP breakdown, causing smooth muscle relaxation, increased blood inflow, and penile erection. Sildenafil has no effect without sexual stimulation.
Pharmacokinetics:
- Absorption: Rapid; peak plasma levels within 30–120 minutes (median 60 min). High-fat meals may delay absorption.
- Metabolism: Primarily hepatic via CYP3A4, minor via CYP2C9. Active metabolite has similar properties.
- Excretion: Mostly in feces (~80%), some in urine (~13%).
- Half-life: ~4 hours.
- Special Populations: Elderly (>65) show reduced clearance, increasing plasma exposure.
Immense is indicated for the treatment of:
Erectile dysfunction (ED) in men, characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Sexual stimulation is required for Immense to be effective.
Pulmonary arterial hypertension (PAH).