-5%
Amlodipine, a dihydropyridine-type calcium channel blocker, lowers blood pressure by inhibiting calcium ion entry into vascular smooth muscle and cardiac muscle, with a more pronounced effect on blood vessels. This results in vasodilation and decreased peripheral vascular resistance.
Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB), works by selectively blocking the binding of angiotensin II to the AT1 receptors in tissues such as vascular smooth muscle and the adrenal glands. This action inhibits vasoconstriction and aldosterone release without interfering with the ACE enzyme, allowing for effective blood pressure reduction without affecting bradykinin metabolism.
Abecab is prescribed for managing high blood pressure, either alone or with other antihypertensive medications. It may be used as an initial treatment in patients expected to require multiple agents to reach their target blood pressure. The decision to begin therapy with this combination should be individualized, considering factors such as the patient’s initial blood pressure levels, the target BP, and the likelihood of reaching the goal with combination therapy versus monotherapy. Blood pressure goals may differ depending on the individual’s cardiovascular risk profile.