-5%
Abetis is prescribed for the management of high blood pressure (hypertension). It can be used as a standalone treatment or combined with other antihypertensive medications.
Olmesartan medoxomil is an angiotensin II receptor blocker (ARB). Angiotensin II, a potent vasoconstrictor, is formed from angiotensin I via the enzyme ACE (angiotensin-converting enzyme). It plays a critical role in regulating blood pressure by constricting blood vessels, promoting aldosterone secretion, increasing sodium reabsorption in the kidneys, and stimulating the heart.
Olmesartan selectively blocks angiotensin II from binding to AT₁ receptors on vascular smooth muscles, thereby preventing vasoconstriction. While AT₂ receptors exist in various tissues, they are not directly involved in blood pressure regulation. Olmesartan has a very high affinity for AT₁ receptors—over 12,500 times greater than for AT₂ receptors.
Unlike ACE inhibitors, olmesartan does not inhibit kininase II, so it does not interfere with bradykinin responses. Though blocking angiotensin II receptors may increase renin activity and circulating angiotensin II levels, these do not negate its antihypertensive action.