-4%
Acne is a complex skin disorder involving increased sebum secretion, abnormal keratinization, bacterial overgrowth, and inflammation. Testosterone and dihydrotestosterone (DHT) act as key factors by binding to androgen receptors, activating genes responsible for sebocyte proliferation, sebum overproduction, and inflammatory cytokine release. Clascoterone competes with these hormones, blocking receptor activation and preventing acne progression.
Additionally, androgenetic alopecia is a genetic, hormone-driven condition where DHT binds to androgen receptors in scalp dermal papilla cells, triggering hair loss. By preventing DHT interaction, Clascoterone inhibits this process, reducing hair thinning.
Acnev cream is an androgen receptor blocker used for treating acne vulgaris in individuals aged 12 years and above.
Clascoterone (cortexolone 17 α-propionate) is a novel androgen receptor antagonist. It binds with high affinity, inhibiting androgen receptor signaling pathways that contribute to acne development, such as sebaceous gland growth, excessive sebum production, and inflammation.