Atrizin Syrup

Indications of Atrizin Syrup 

It is suitable for alleviating symptoms associated with seasonal and perennial allergic rhinitis. It is also suitable for the treatment of simple skin manifestations of chronic idiopathic urticaria and allergen-induced asthma.

Pharmacology of Atrizin Syrup 

Cetirizine hydrochloride is an effective H1 receptor antagonist and has no significant anticholinergic or antiserum effects. At the pharmacologically active dose level, it has almost no drowsiness and does not cause behavior changes. It inhibits the early stages of histamine-mediated allergic reactions and reduces the migration of inflammatory cells and the release of mediators related to the late stages of allergic reactions. 

Pharmacokinetics: Cetirizine 10 mg reaches a peak plasma concentration of 257 mcg/L (980 mcg/L in children) within 1 hour after administration. Food does not affect the degree of absorption, but it may slow down slightly. A maximum blood concentration of 0.3 μg/ml is reached 30 to 60 minutes after taking a 10 mg dose of cetirizine. Its plasma half-life is approximately 11 hours. The absorption from one object to another is very constant. Its renal clearance rate is 30 ml/min, and its excretion half-life is approximately 9 hours.

Dosage & Administration of Atrizin Syrup 

Adults and children 6 years and older: 1 tablet or 2 teaspoons a day (or 1 teaspoon twice a day).

• 26-year-olds: 1 teaspoon once a day or 1/2 teaspoon twice a day.
• Children from 6 months to 2 years: 1/2 teaspoon once a day. The dose for children aged 12 to 23 months can be increased to the maximum dose of 1/2 teaspoon every 12 hours.

Interactions of Atrizin Syrup 

No clinically significant drug interactions with theophylline, azithromycin, pseudoephedrine, ketoconazole, erythromycin, and other drugs have been found.

Contraindications of Atrizin 10mg

Patients who have a history of allergy to cetirizine or hydroxyzine are contraindicated.

Side-Effects of Atrizin Syrup 

The most common side effect of cetirizine is drowsiness.

Pregnancy & Lactation

The United States FDA classifies cetirizine hydrochloride as pregnancy classification B. However, there are no adequate and well-controlled studies on pregnant women. Because animal reproduction research does not always predict human response, the drug should be used during pregnancy only when clearly necessary. Cetirizine hydrochloride has been shown to be excreted from human milk. Therefore, care should be taken when administering cetirizine hydrochloride to lactating women.

Precautions & Warning of Atrizin Syrup 

• Compared to other similar medications, it is far less likely to make you feel tired.
• As Atrizin 10 has low drug interactions, it is safe to take it with the majority of other medications.
• Because Atrizin 10 can make you feel drowsy and lightheaded, exercise caution when driving or performing other tasks that call for concentration.
• When using Atrizin 10, avoid drinking alcohol as it may make you feel more sleepy.
• Atrizin 10 should be stopped at least three days prior to an allergy test as it may alter the results.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.