-5%
Azithromycin is acid-stable and well-absorbed when taken orally, with enhanced absorption on an empty stomach. Peak plasma levels occur within 2.1–3.2 hours. It accumulates significantly in phagocytes and is delivered directly to infection sites, where it is released during phagocytosis. Tissue concentrations can be over 50 times greater than plasma levels due to lipid solubility and ion trapping.
The drug has a long half-life, allowing for once-daily or short-course dosing. After a single 500 mg dose, azithromycin exhibits a terminal half-life of about 68 hours. It is mainly eliminated via bile in an unchanged form, with only 6% excreted unchanged in urine over one week.
Azin is prescribed for infections caused by susceptible organisms. These include:
- Lower respiratory tract infections (e.g., bronchitis, pneumonia)
- Upper respiratory tract infections (e.g., sinusitis, pharyngitis, tonsillitis)
- Otitis media
- Skin and soft tissue infections
- Sexually transmitted infections, such as non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis
To ensure effectiveness, complete the entire prescribed course of Azin 500 mg, even if symptoms improve early. Premature discontinuation may result in relapse and resistance.
Common side effects include diarrhea, which usually resolves after treatment ends. Consult a doctor if it persists or if there’s blood in stool. Discontinue use and seek immediate medical help if you experience symptoms like rash, facial or throat swelling, or breathing difficulty.
Take Azin 500 mg orally 1 hour before or 2 hours after meals. Avoid taking antacids within 2 hours before or after taking this medicine.