-5%
Betaloc (Metoprolol) | Therapeutic Class: Selective β1-blocker
- Hypertension
- Angina pectoris
- Cardiac arrhythmias (esp. supraventricular)
- Adjunct in hyperthyroidism
- Early intervention in acute myocardial infarction (reduces infarct size & mortality)
Mechanism: Selective β1-blockade → reduces heart rate, cardiac output, BP, and contractility by inhibiting catecholamine effects.
Less interference with insulin release & carbohydrate metabolism than non-selective β-blockers.
Special Precautions
- Bronchospastic disease → use cautiously
- Surgery → may impair cardiovascular reflexes
- Diabetes → may mask hypoglycemia symptoms
- Peripheral vascular disease → may worsen symptoms
- Hepatic impairment → adjust dose
- Pediatrics: safety not established <6 y