-5%
Tablet Manufacturer/Distributor: General Pharmaceuticals Ltd. Generic Name: Caffeine 65 mg + Paracetamol 500 mg Tablet
Indications
Indicated in the following condition
- Headache
- Migraine
- Toothache
- Nervous pain
- Nervousness
- Menstrual pain
- Sore throat
- Back pain
- Helps lower temperature
- Colds and flu
Pharmacology
It is a combination of paracetamol and caffeine. Paracetamol has analgesic and antipyretic properties with low anti-inflammatory activity. Caffeine is an alkaloid derived from xanthine theophylline. By intermolecular bonding with paracetamol, caffeine increases the solubility and membrane permeability of paracetamol. Additionally, caffeine increases the pain threshold and pain tolerance. Caffeine also has the inherent power to increase the tone of blood vessels in the brain, providing another benefit for treating migraines and headaches.
Dosage and Administration
Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.
Child dose: Not recommended for children below 12 years.
Interaction
It is possible to reduce serum drug concentrations with anticonvulsants (eg, phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use. Acceleration of absorption with metoclopramide and domperidone. There may be an increase in serum concentrations with probenecid. May increase serum concentrations of chloramphenicol. Absorption with colestyramine may be reduced within 1 hour of administration. May cause severe hypothermia with phenothiazines.
Contraindications
Paracetamol is contraindicated in patients with severe renal impairment and liver disease (viral hepatitis). Hypersensitivity to paracetamol or caffeine.
Side Effect
Side effects of paracetamol are generally mild, although hematological reactions including thrombocytopenia, leukopenia, thrombocytopenia, leukopenia, and agranulocytosis have been reported. Sometimes pancreatitis, rashes, and other allergic reactions occur.
Pregnancy & Lactation
Pregnant women should consult their doctor before taking paracetamol and caffeine. You can take paracetamol and caffeine while breastfeeding.
Precautions & Warnings
Paracetamol and caffeine should be used with caution in the following cases: in patients with hepatic or renal insufficiency, and in patients receiving other hepatotoxic drugs. Prolonged use of the drug should be avoided without consulting a doctor.
Storage Conditions
Store in a cool and dry place, protect from light and moisture. Keep all medicines out of the reach of the children.