-5%
Ciclorox 1% Shampoo is a medicated shampoo specifically designed for the treatment of scalp conditions such as:
- Seborrheic dermatitis
- Dandruff (pityriasis capitis)
- Scalp inflammation and swelling
It helps relieve itchiness, flaking, and irritation associated with fungal overgrowth and inflammatory responses on the scalp.
Pediatric use: Safety and effectiveness have not been established in children under 16 years of age due to a lack of sufficient clinical trial data.
Ciclopirox Olamine is a synthetic, broad-spectrum antifungal compound with both fungistatic and fungicidal properties. It effectively targets:
- Dermatophytes: e.g., Trichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum, Microsporum canis
- Yeasts: e.g., Candida albicans, and
- Malassezia furfur, a fungus commonly linked to dandruff and seborrheic dermatitis.
- The antifungal mechanism primarily involves:
- Disruption of fungal cell metabolism by interfering with the uptake of essential substrates and metal ions, which are necessary for fungal growth and survival.
- In addition to antifungal activity, Ciclopirox exhibits:
- Antibacterial effects against a range of both Gram-positive and Gram-negative bacteria.
- Anti-inflammatory properties, demonstrated by its ability to:
- Inhibit the production of pro-inflammatory mediators like prostaglandins and leukotrienes.
- Block key enzymes such as 5-lipoxygenase and cyclooxygenase, involved in inflammation pathways.
This triple-action profile (antifungal, antibacterial, anti-inflammatory) makes it highly effective in treating scalp conditions with both microbial and inflammatory components.