-5%
Ciprofloxacin, the active ingredient, is a synthetic quinolone antibiotic with broad-spectrum activity. It is highly effective against many gram-negative aerobic bacteria, including Enterobacteriaceae and Pseudomonas aeruginosa, and also active against certain gram-positive bacteria, including penicillin-resistant Staphylococcus aureus. Its bactericidal action results from inhibition of bacterial DNA gyrase, an enzyme critical for DNA synthesis.
After oral administration, ciprofloxacin is rapidly absorbed, widely distributed in tissues, and has a half-life of ~3.5 hours. Around 30–50% of an oral dose is excreted unchanged in the urine within 24 hours, along with active metabolites.
Ciprozid-XR is prescribed for treating single or mixed infections caused by two or more susceptible organisms. It is also effective against infections caused by bacteria resistant to other antibiotics, including aminoglycosides, penicillins, and cephalosporins.
As it achieves therapeutic concentrations in the blood, tissues, and urine after oral administration, Ciprozid-XR is suitable for treating a wide range of infections, including urinary, respiratory, and gastrointestinal tract infections, gonorrhea, and septicemia. Its broad tissue penetration and strong antibacterial effect—especially against Pseudomonas aeruginosa—allow it to be used alone (pending sensitivity tests) or in combination with other antibiotics, such as aminoglycosides or beta-lactams, particularly in severe neutropenia or suspected anaerobic infections (e.g., Bacteroides fragilis).
Specific indications include:
- Severe systemic infections: septicemia, bacteremia, peritonitis, infections in immunocompromised patients (such as those with hematologic cancers, solid tumors, or in ICU with burn infections).
- Respiratory tract: lobar and bronchopneumonia, acute/chronic bronchitis, cystic fibrosis exacerbations, bronchiectasis, empyema.
- Urinary tract: uncomplicated/complicated urethritis, cystitis, pyelonephritis, prostatitis, epididymitis.
- Skin and soft tissue: infected ulcers, wound infections, abscesses, cellulitis, otitis externa, erysipelas, infected burns.
- Gastrointestinal: typhoid fever, infectious diarrhea.
- Biliary tract: cholangitis, cholecystitis, gallbladder empyema.
- Intra-abdominal: peritonitis, intra-abdominal abscess.
- Bone/joint: osteomyelitis, septic arthritis.
- Pelvic: salpingitis, endometritis, pelvic inflammatory disease.
- ENT and eye infections: otitis media, sinusitis, mastoiditis, tonsillitis.
- Gonorrhea: urethral, rectal, and pharyngeal infections caused by beta-lactamase-producing or penicillin-resistant strains.