-5%
CTZ is used to relieve symptoms of:
- Seasonal & perennial allergic rhinitis
- Chronic idiopathic urticaria (persistent hives)
- Asthma triggered by allergens
Cetirizine is a selective H1-antihistamine:
- Blocks histamine effects during allergic reactions
- Reduces inflammation by stopping histamine-related cell migration
- Has minimal sedative effects and doesn’t impact behavior
Pharmacokinetics
Peak level in adults: ~257 mcg/L within 1 hour (faster in children)
Half-life: ~11 hours
Absorption: Consistent, not significantly affected by food
Excretion: Mostly via urine (renal clearance ~30 ml/min)