-2%
Dexlansoprazole is a proton pump inhibitor (PPI) that reduces gastric acid secretion by selectively blocking the H⁺/K⁺-ATPase enzyme in the stomach’s parietal cells. By inhibiting this proton pump, it suppresses the final stage of gastric acid production.
Dexlansoprazole is the R-enantiomer of lansoprazole and is formulated using a Dual Delayed Release (DDR) system. The capsule contains two types of enteric-coated granules that dissolve at different pH levels, producing two separate peaks in blood concentration. The first peak generally occurs within 1–2 hours, followed by a second peak around 4–5 hours after administration. Dexlansoprazole is extensively metabolized in the liver, with its metabolites primarily eliminated through urine.
- Healing of Erosive Esophagitis: Dextac is used to heal all grades of erosive esophagitis (EE) for up to 8 weeks.
- Maintenance of Healed Erosive Esophagitis: It helps maintain the healing of EE and provides relief from heartburn for up to 6 months.
- Symptomatic Non-Erosive GERD: Dextac is indicated for relieving heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD) for 4 weeks.
Dextac may be taken with or without food. Swallow the capsule whole without crushing or chewing it.
If necessary, the capsule may be opened and the intact granules sprinkled over one tablespoon of food and swallowed immediately. The granules should not be chewed.
If a dose is missed, take it when remembered unless it is nearly time for the next dose. In that case, skip the missed dose and take the next dose at the regular time. Do not take a double dose.