-5%
Phenytoin stabilizes neuronal membranes by modulating sodium ion movement during nerve impulse generation in the motor cortex. This mechanism:
- Anticonvulsant Effect: Reduces seizure activity by decreasing neuronal excitability.
- Antiarrhythmic Effect: Extends the refractory period and suppresses ventricular pacemaker automaticity, thus stabilizing cardiac rhythm.
Phenytoin – an anticonvulsant and antiarrhythmic agent.
- Status Epilepticus (Grand Mal Type): Effective in the treatment of prolonged seizures.
- Seizure Prevention During Neurosurgery: Used prophylactically in patients undergoing brain surgery.