-5%
Dotfix 2 is a medication used for the treatment of gout and hyperuricemia. Gout is an inflammatory condition caused by the deposition of urate crystals in the joints, often due to prolonged high levels of uric acid in the blood (hyperuricemia). Dotfix 2 works by inhibiting URAT1, a specific urate transporter, which helps reduce the reabsorption of uric acid in the kidneys and increases its excretion through urine. This lowers the overall levels of serum uric acid, which is beneficial for managing both acute gout attacks and preventing their recurrence in patients with chronic hyperuricemia.
Dotfix is used for the treatment of gout and hyperuricemia (high levels of uric acid in the blood).
Note: Always use under the guidance of a registered healthcare provider.
Dotinurad is a URAT1-selective urate reabsorption inhibitor that blocks URAT1, a transporter responsible for reabsorbing uric acid in the kidneys. By inhibiting this transporter, Dotinurad increases the excretion of uric acid in urine and helps lower serum uric acid levels. It is designed to selectively target URAT1 without affecting other transporters like ABCG2, OAT1, and OAT3, which also affect uric acid secretion. This high selectivity makes Dotinurad effective in lowering uric acid levels while minimizing the risk of disrupting uric acid secretion pathways.