Encorate Chrono 300mg 10pcs

Sodium Valproate is indicated for –
 

• Epilepsy: All types of epilepsy such as Absence seizure, Myoclonic seizure, Tonic-clonic seizure, Atonic, Mixed, simple or generalized, Secondary generalized seizure etc.
• Mania: For the treatment of manic episodes of bipolar disorders.
• Other: As an alternative treatment for febrile convulsion & migraine prophylaxis.

Dosage: 

Adults:
 

• Initial: 600 mg/day in 2 divided doses, preferably after food. Dose may be increased by 200mg/day at 3 days interval to a maximum of 2.5 gm daily in divided doses until control of seizure is achieved.
• Maintenance dose: Usually 1-2 gm daily (20-30 mg/kg daily).

Children (up to 20 kg):
 

• Initial: 20 mg/kg daily in divided doses. Dose may be increased in severe cases with proper monitoring of plasma concentration.

Children (over 20 kg):
 

• Initial: 400 mg/ day (irrespective of weight). Dose may be increased by 20-30 mg/ kg if required to achieve control.

Side effects: Gastric irritation, nausea, ataxia & tremor; hyperammonaemia, increased appetite & weight gain; transient hair loss, oedema, thrombocytopenia, and inhibition of platelet aggregation, impaired hepatic function leading rarely to fetal hepatic failure; rashes; sedation; rarely lethargy and confusion and also increased alertness; rarely pancreatitis, leucopenia, pancytopenia, red cell hypoplasia, fibrinogen reduction; irregular periods, amenorrhoea, gynaecomastia, toxic epidermal necrolysis, hearing loss, Fancoli’s syndrome, dementia, Steven’s-Johnson syndrome, and vasculitis have also been reported.