-5%
- Eplerenone is a selective aldosterone receptor antagonist that works by blocking aldosterone binding at the mineralocorticoid receptor.
- Aldosterone, a key component of the renin-angiotensin-aldosterone system (RAAS), plays a role in blood pressure regulation by promoting sodium retention and potassium excretion in the kidneys.
- Eplerenone prevents aldosterone from exerting its effects, leading to:
- Reduced sodium reabsorption
- Lower blood pressure
- Decreased fluid retention
- It has also been shown to increase plasma renin activity and aldosterone levels as a compensatory response, but these increases do not override its therapeutic effect.
Eplerenone
