-2%
Histamine acts on H1 receptors and plays a key role in allergic responses. When allergens trigger mast cells and basophils, histamine is released, leading to symptoms such as itching, sneezing, watery eyes, and nasal discharge.
Fexofenadine is a selective H1-receptor antagonist (inverse agonist). It stabilizes the inactive form of the H1 receptor, preventing histamine from activating allergic responses. Unlike many antihistamines, it does not cause sedation because it does not cross the blood–brain barrier and has no significant anticholinergic or CNS effects.
1. Allergic Rhinitis
Fexomin is indicated for the relief of symptoms associated with both seasonal and perennial allergic rhinitis in adults and children aged 12 years and above. It effectively relieves sneezing, runny nose, watery eyes, and itching of the nose, throat, palate, and eyes. It also helps improve daily functioning and quality of life, including work and activity performance.
2. Chronic Idiopathic Urticaria
Fexomin is also used to treat chronic idiopathic urticaria in adults and adolescents (12 years and older). It reduces hives (wheals) and itching, helping improve overall comfort and quality of life, as well as daily productivity..