-5%
Flupen is prescribed for treating infections caused by Gram-positive bacteria, including penicillinase-producing staphylococci. It is commonly used for:
✔ Skin and soft tissue infections – boils, abscesses, carbuncles, infected ulcers, eczema, acne, furunculosis, cellulitis, infected wounds and burns, otitis media and externa, and impetigo.
✔ Respiratory tract infections – pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy.
✔ Other infections – osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, and septicemia.
✔ Surgical prophylaxis – Used before major procedures such as cardiothoracic and orthopedic surgeries.
Flucloxacillin is a penicillinase-resistant antibiotic effective against Gram-positive bacteria but has minimal effect on Gram-negative organisms. It works by inhibiting bacterial cell wall synthesis, preventing bacterial growth and replication.
✔ It interferes with peptidoglycan synthesis, a crucial component that strengthens bacterial cell walls.
✔ It inhibits transpeptidase enzymes, leading to cell wall weakening and bacterial rupture.
✔ Flucloxacillin is resistant to bacterial penicillinase, making it effective against penicillin-resistant staphylococci.