-2%
Folinic Acid (Calcium folinate)
- Colorectal Cancer: Used as an adjunct to fluorouracil for chemotherapy treatment.
- Methotrexate Toxicity: Acts as an antidote for the toxicity caused by methotrexate.
- Folate-Deficient Megaloblastic Anaemia: To treat folate deficiency-related anemia.
Folinic acid (calcium folinate) enters cells as 5-methyl tetrahydrofolate, providing the necessary cofactor that is blocked by methotrexate.
- It stabilizes the binding of 5-dUMP to thymidylate synthetase and enhances the activity of fluorouracil.
- It neutralizes the toxic effects of methotrexate while increasing the efficacy of fluorouracil.
