-2%
Glimepiride, a sulfonylurea antidiabetic, works mainly by stimulating insulin secretion from functional pancreatic β-cells.
It enhances β-cell sensitivity to glucose, promoting insulin release in response to physiological glucose levels.
It also improves peripheral insulin sensitivity, increases glucose uptake in tissues, and reduces hepatic glucose production.
A single dose provides 24-hour hypoglycemic control in non-fasting diabetic patients.
Glucorid is used as an adjunct to diet and exercise for reducing blood glucose levels in patients with Type 2 Diabetes Mellitus (NIDDM) whose hyperglycemia is not adequately controlled by lifestyle measures alone.
- It can be prescribed alone or with metformin when either medication alone fails to achieve adequate glycemic control.
- Glucorid may also be used in combination with insulin in patients whose blood sugar remains uncontrolled with oral agents and lifestyle modifications.
- Combined use with insulin may increase the risk of hypoglycemia and requires close monitoring.