-5%
Vildagliptin + Metformin Hydrochloride is prescribed alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who are not adequately managed on Metformin Hydrochloride or Vildagliptin alone, or who are already receiving both drugs separately.
Vildagliptin works by inhibiting the enzyme DPP-4 (Dipeptidyl peptidase-4), which breaks down incretin hormones like GLP-1 and GIP. This inhibition boosts levels of these hormones, leading to increased insulin release from pancreatic beta cells and reduced glucagon release from alpha cells, particularly during high blood sugar, thereby lowering glucose production in the liver and reducing blood sugar levels.
Metformin Hydrochloride, a biguanide oral antidiabetic, lowers both fasting and post-meal glucose without causing hypoglycemia. It works by reducing glucose production in the liver, decreasing glucose absorption in the intestines, and enhancing insulin sensitivity to improve glucose uptake and use in tissues.