-5%
Indapamide, the active ingredient in Idatix SR, is an oral antihypertensive agent. Its mechanism of action is not entirely understood but involves both vascular and renal effects. Potential benefits of Indapamide in treating hypertension include reducing cardiac hypertrophy and arterial wall thickening, preventing fibronectin accumulation in coronary vessels, scavenging free radicals to stimulate vasodilator eicosanoid production, and interacting with renal carbonic anhydrase. Its primary site of action in the kidney is the proximal segment of the distal tubule, where it promotes sodium and chloride excretion with minimal impact on potassium or uric acid levels. Urinary volume increase is noticeable only at doses exceeding 1.5 mg per day. Clinical studies have not observed significant changes in plasma sodium levels, although hypokalemia (potassium <3.2 mmol/L) has been reported in 4% of patients.
