-5%
- Indapamide is a thiazide-like oral antihypertensive
- Acts on the distal tubule with natriuretic effects (excretes sodium & chloride)
- Minimal kaliuresis or uric acid loss
- Improves vascular tone, reduces cardiac hypertrophy & arterial wall thickening
- Half-life: ~18 hrs; steady state achieved in 7 days
- Excretion: urine (70%), feces (22%) as metabolites
Indapamide 1.5
- Essential hypertension
- Effective in patients with renal impairment (though diuretic effect may be reduced)
- Salt & fluid retention in congestive heart failure
- Can be combined with other antihypertensives in severe cases